Bromobenzene → HCID 21993536, compound

HRID 1977665Notes

Reaction equation

HRID 1977665 reaction equation
[CH3:1][C:2]([NH:4][C:5]1[CH:10]=[CH:9][CH:8]=[C:7]([F:11])[CH:6]=1)=[O:3].Br[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1>>[F:11][C:7]1[CH:6]=[C:5]([N:4]([C:2](=[O:3])[CH3:1])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:10]=[CH:9][CH:8]=1

Participants

3

Reactant 2

HCID 7961BromobenzeneHCID 9594N-(3-Fluorophenyl)acetamide

Product 1

HCID 21993536HCID 21993536, compoundYield 21.2%

Procedure

Using 3-fluoroacetanilide (4.6 g) and bromobenzene (9.4 g), a reaction was made in the same manner as in 1) of Production Example 14. The subsequent purification by silica gel column chromatography (developing solvent, ethyl acetate:hexane=1:2) produced 3-fluoro-N-phenylacetanilide (1.46 g; yield, 21%) as a purple oil.

Workup

  1. customThe subsequent purification by silica gel column chromatography (developing solvent, ethyl acetate:hexane=1:2)

Sources & evidence

ORD record
ord-6060048376854ac9acfdee574857f168
Source dataset
uspto-grants-2001_05
Patent number
US06235730B1

Reaction notes

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