Ethylene carbonate → HCID 21995164, compound

HRID 1977678Notes

Reaction equation

HRID 1977678 reaction equation
OCCO[C:5]1[CH:6]=[C:7]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH:17][C:18]3[CH:23]=[C:22]([O:24][CH3:25])[C:21]([O:26][CH3:27])=[C:20]([O:28][CH3:29])[CH:19]=3)[N:12]=2)[CH:8]=[CH:9][CH:10]=1.OC1C=CC(C2C=CN=C(NC3C=[C:48]([O:50]C)[C:47]([O:52]C)=C(OC)C=3)N=2)=CC=1.C1(=O)OCCO1.[H-].[Na+]>>[OH:50][CH2:48][CH2:47][O:52][C:10]1[CH:5]=[CH:6][C:7]([C:11]2[CH:16]=[CH:15][N:14]=[C:13]([NH:17][C:18]3[CH:19]=[C:20]([O:28][CH3:29])[C:21]([O:26][CH3:27])=[C:22]([O:24][CH3:25])[CH:23]=3)[N:12]=2)=[CH:8][CH:9]=1

Participants

5

Reactant 4

HCID 7303Ethylene carbonateHCID 24758Sodium hydrideHCID 21995220HCID 21995220, compoundHCID 135815278HCID 135815278, compound

Product 1

HCID 21995164HCID 21995164, compound

Procedure

The compound was prepared in a manner analogous to the preparation of the compound of Example 47 from the compound of Example 49 (250 mg, 0.71 mmol), ethylene carbonate (70 mg, 6.78 mmol) and 60% sodium hydride (dispersion in oil) (30 mg, 0.78 mmol) to give the title compound (140 mg) as a yellow solid m.p 145-146°. MS m/z 398 (M+H)+.

Sources & evidence

ORD record
ord-7be1c29a5aee40409c43250a5716cca3
Source dataset
uspto-grants-2001_05
Patent number
US06235746B1

Reaction notes

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