反应详情

温度

-78 °C

24 ml of dried tetrahydrofuran solution of 2.34 g (18.81 mM) of methyl methylsulfinyl-methyl sulfide was cooled to 0° C. A hexane solution of n-butyl lithium (18.81 mM) was added dropwise to the solution and was stirred for around 30 minutes at the same temperature. The solution was cooled to −78° C., and solution of 5.00 g (15.47 mM) 3,4-dimethoxybenzylidenemalonic acid diethyl ester in 2 ml of dried tetrahydrofuran was added. The solution thus obtained was heated gradually to room temperature, poured to an aqueous ammonium chloride solution, and was extracted with diethyl ether. The organic extract was dried over anhydrous magnesium sulfate, then the solvent was evaporated in vacuo to obtain 6.70 g crude product of brown oily 3-(3,4-dimethoxyphenyl)-2-ethoxycarbonyl-4-methylsulfinyl-4-methylthiobutyric ethyl ester. The crude product was dissolved in 25 ml of anhydrous ethanol, 3.09 g (20.88 mM) of ethyl orthoformate and 0.25 ml of sulfuric acid were added thereto, and the mixture was stirred for 3 days at room temperature. The solution was poured to an aqueous sodium hydrogencarbonate under ice cooling and was extracted with diethyl ether. The organic extract was dried, then the solvent was evaporated in vacuo to obtain a brown oily crude product. The crude product was purified by chromatography. The product was concentrated and dried in vacuo to obtain 5.08 g of yellow oily 3-(3,4-dimethoxyphenyl)-4,4-diethoxy-2-ethoxycarbonylbutyric acid ethyl ester (yield 79.5%).

1. customThe solution thus obtained
2. temperaturewas heated gradually to room temperature
3. extractionwas extracted with diethyl ether
4. extractionThe organic extract
5. dry with materialwas dried over anhydrous magnesium sulfate
6. customthe solvent was evaporated in vacuo
7. customto obtain 6.70 g crude product of brown oily 3-(3,4-dimethoxyphenyl)-2-ethoxycarbonyl-4-methylsulfinyl-4-methylthiobutyric ethyl ester
8. stirringthe mixture was stirred for 3 days at room temperature
9. extractionwas extracted with diethyl ether
10. extractionThe organic extract
11. customwas dried
12. customthe solvent was evaporated in vacuo
13. customto obtain a brown oily crude product
14. customThe crude product was purified by chromatography
15. concentrationThe product was concentrated
16. customdried in vacuo