反应详情

8 g of 2-tert-Butyl-4-methyl-phenol (49 mmol) and 16.36 g of potassium carbonate (58 mmol) were stirred in 120 ml DMF until a suspension was formed. 6.74 ml of benzylchloride were then added dropwise and the reaction mixture was stirred for 24 h at RT. After two hours heating at 60° C., the reaction mixture was cooled to RT, filtered off, diluted with ethyl acetate, and washed with water followed by brine. The organic phase was dried over magnesium sulphate, filtered off and concentrated under vacuo. The residue was purified by flash column chromatography (heptane/AcOEt 98/2) to give 8.647 g of a colorless liquid. MS (ISP) 255.3 (M+H)+.

1. customwas formed
2. temperatureAfter two hours heating at 60° C.
3. temperaturethe reaction mixture was cooled to RT
4. filtrationfiltered off
5. additiondiluted with ethyl acetate
6. washwashed with water
7. dry with materialThe organic phase was dried over magnesium sulphate
8. filtrationfiltered off
9. concentrationconcentrated under vacuo
10. customThe residue was purified by flash column chromatography (heptane/AcOEt 98/2)