Methanesulfonic Acid → HCID 86756745, compound

HRID 1978079Notes

Reaction equation

[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].O1CCCCC1[O:12][NH:13][C:14]([C@H:16]([C@@H:26]([CH2:42][CH:43]([CH3:45])[CH3:44])[C:27]([NH:29][N:30]([S:38]([CH3:41])(=[O:40])=[O:39])[CH2:31][C:32]1[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=1)=[O:28])[CH2:17]/[CH:18]=[CH:19]/[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:15]>>[CH3:1][S:2]([OH:5])(=[O:4])=[O:3].[OH:12][NH:13][C:14]([C@H:16]([C@@H:26]([CH2:42][CH:43]([CH3:45])[CH3:44])[C:27]([NH:29][N:30]([S:38]([CH3:41])(=[O:40])=[O:39])[CH2:31][C:32]1[CH:33]=[N:34][CH:35]=[CH:36][CH:37]=1)=[O:28])[CH2:17]/[CH:18]=[CH:19]/[C:20]1[CH:25]=[CH:24][CH:23]=[CH:22][CH:21]=1)=[O:15]

Participants

Reactant 2

HCID 6395Methanesulfonic Acid

HCID 86756747HCID 86756747, compound

Product 1

HCID 86756745HCID 86756745, compound

Procedure

In a manner analogous to that described in the first paragraph of Example 2, but using methanesulphonic acid in place of p-toluenesulphonic acid, starting from 0.2 g of (E)-2(R)-[1(S)-[(tetrahydro-2(RS)-pyranyloxy)carbamoyl]-4-phenyl-3-butenyl]-2′-(methanesulphonyl)-4-methyl-2′-[(3-pyridyl)methyl]valerohydrazide there was obtained 0.177 g of (E)-2(R)-[1(S)-(hydroxycarbamoyl)-4-phenyl-3-butenyl]-2′-(methanesulphonyl)-4-methyl-2′-[(3-pyridyl)methyl]valerohydrazide methanesulphonate in the form of an orange solid.

Sources & evidence

ORD record: ord-9320e3871aa344879a6fe01d14877fb3
Source dataset: uspto-grants-2001_05
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US06235787B1

Reaction notes

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