Hexafluoroacetone → 1,1,1,3,3,3-Hexafluoro-2-propanol

HRID 1978250Notes

Reaction equation

HRID 1978250 reaction equation
[F:1][C:2]([F:10])([F:9])[C:3]([C:5]([F:8])([F:7])[F:6])=[O:4].[H][H]>[Pd]>[CH:3]([OH:4])([C:5]([F:8])([F:7])[F:6])[C:2]([F:10])([F:9])[F:1]

Participants

4

Reactant 2

HCID 12695HexafluoroacetoneHCID 178418361HCID 178418361, compound

Product 1

HCID 135291,1,1,3,3,3-Hexafluoro-2-propanolYield 90%

Reagents, catalysts & solvents 1

HCID 23938PalladiumCatalyst

Procedure

Approximately 100cc of Pd/C catalyst is packed into a ½″ diameter pipe reactor. Approximately 1 g/min of the hexafluoroacetone and 500cc/min hydrogen gas is fed into the reactor at atmospheric pressure and 180° C. Hexafluoro-2-propanol is produced in greater than 90% yield.

Workup

  1. customis fed into the reactor at atmospheric pressure and 180° C

Sources & evidence

ORD record
ord-c0a60bd35ca942bbbb3d589ef84535ae
Source dataset
uspto-grants-2001_05
Patent number
US06235950B1

Reaction notes

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