HCID 14235690, compound → HCID 131722576, compound

HRID 1978285Notes

Reaction equation

HRID 1978285 reaction equation
[NH:1]([C:22]([O:24][CH2:25][C:26]1[CH:31]=[CH:30][CH:29]=[CH:28][CH:27]=1)=[O:23])[C@H:2]([C:11]([NH:13][CH2:14][CH2:15][C:16]1[CH:21]=[CH:20][CH:19]=[CH:18][CH:17]=1)=[O:12])[CH2:3][C:4](=[O:10])[O:5]C(C)(C)C>FC(F)(F)C(O)=O>[NH:1]([C:22]([O:24][CH2:25][C:26]1[CH:27]=[CH:28][CH:29]=[CH:30][CH:31]=1)=[O:23])[C@H:2]([C:11]([NH:13][CH2:14][CH2:15][C:16]1[CH:17]=[CH:18][CH:19]=[CH:20][CH:21]=1)=[O:12])[CH2:3][C:4](=[O:5])[OH:10]

Participants

3

Reactant 1

HCID 14235690HCID 14235690, compound

Product 1

HCID 131722576HCID 131722576, compoundYield 87%

Reagents, catalysts & solvents 1

HCID 6422Trifluoroacetic acidSolvent

Procedure

The t-butyl ester (10, 100 mg, 0.22 mmol) in trifluoroacetic acid (5 mL) was stirred in an ice bath for 30 minutes. Trifluoroacetic acid was removed under reduced pressure, the crude product was recrystallized from EtOAc/hexane to give 76.8 mg (0.19 mmol, 87% yield) of a pale yellow solid.

Workup

  1. customTrifluoroacetic acid was removed under reduced pressure
  2. customthe crude product was recrystallized from EtOAc/hexane

Sources & evidence

ORD record
ord-655ba1c6c24748afa650429612bd3e35
Source dataset
uspto-grants-2001_05
Patent number
US06235929B1

Reaction notes

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