Hydrogen Bromide → 1,6,12-Triazadodecane Trihydrochloride

HRID 1978292Notes

Reaction equation

HRID 1978292 reaction equation
Br.C1(C)C=C(C)C=C(C)C=1S([N:13]([CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][NH2:24])[CH2:14][CH2:15][CH2:16][CH2:17][NH2:18])(=O)=O.C1(O)C=CC=CC=1.C(Cl)[Cl:34]>>[ClH:34].[ClH:34].[ClH:34].[NH2:18][CH2:17][CH2:16][CH2:15][CH2:14][NH:13][CH2:19][CH2:20][CH2:21][CH2:22][CH2:23][NH2:24]

Participants

5

Reactant 4

HCID 260Hydrogen BromideHCID 996PhenolHCID 6344DichloromethaneHCID 10594392HCID 10594392, compound

Product 1

HCID 219966501,6,12-Triazadodecane TrihydrochlorideYield 50%

Procedure

HBr (30% in HOAC, 33 mL), 41 (2.43 g, 6.83 mmol), and phenol (6 g, 60 mmol) in CH2Cl2 were reacted, and product was isolated by the procedure of 2 to give 0.97 g (50%) of 20 as a hygroscopic solid: NMR (D2O) δ 1.47 (m, 2 H), 1.70-1.80 (m, 8 H), 3.00-3.10 (m, 8 H). Anal. (C9H26Cl3N3) C, H, N.

Workup

  1. customproduct was isolated by the procedure of 2

Sources & evidence

ORD record
ord-d4edea49c79649d493021d85eb2dad07
Source dataset
uspto-grants-2001_05
Patent number
US06235794B1

Reaction notes

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