Hydrogen Bromide → HCID 21996675, compound

HRID 1978297Notes

Reaction equation

HRID 1978297 reaction equation
Br.C1(C)C=C(C)C=C(C)C=1S([N:13]([CH2:15][CH2:16][CH2:17][CH2:18][CH2:19][N:20](S(C1C(C)=CC(C)=CC=1C)(=O)=O)[CH2:21][CH2:22][CH2:23][CH2:24][CH2:25][N:26](S(C1C(C)=CC(C)=CC=1C)(=O)=O)[CH3:27])[CH3:14])(=O)=O.C1(O)C=CC=CC=1.C(Cl)[Cl:61]>>[ClH:61].[ClH:61].[ClH:61].[CH3:27][NH:26][CH2:25][CH2:24][CH2:23][CH2:22][CH2:21][NH:20][CH2:19][CH2:18][CH2:17][CH2:16][CH2:15][NH:13][CH3:14]

Participants

5

Reactant 4

HCID 260Hydrogen BromideHCID 996PhenolHCID 6344DichloromethaneHCID 10676606HCID 10676606, compound

Product 1

HCID 21996675HCID 21996675, compoundYield 76%

Procedure

HBr (30% in HOAc, 30 mL), 55 (1.48 g, 1.94 mmol), and phenol (5.2 g, 55 mmol) in CH2Cl2 (30 mL) were reacted, and product was isolated by the method of 2 to produce 480 mg (76%) of 25 as needles: NMR (D2O) δ 1.4-1.5 (quintet, 4 H), 1.7-1.8 (quintet, 8 H), 2.7 (s, 6 H), 3.05 (t, 8 H, J=7). Anal. (C12H32Cl3N3) C, H, N.

Workup

  1. customproduct was isolated by the method of 2

Sources & evidence

ORD record
ord-8751c638d8304d92809ac340ed0d82b5
Source dataset
uspto-grants-2001_05
Patent number
US06235794B1

Reaction notes

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