Hydrochloric Acid → HCID 21993863, compound

HRID 1978317Notes

Reaction equation

HRID 1978317 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH:14]2[CH2:19][CH2:18][N:17]([CH2:20][CH2:21][CH2:22][C:23]3[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=3)[CH2:16][CH2:15]2)[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:29]>CO>[ClH:29].[ClH:29].[C:23]1([CH2:22][CH2:21][CH2:20][N:17]2[CH2:18][CH2:19][CH:14]([CH:11]3[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]3)[CH2:15][CH2:16]2)[CH:28]=[CH:27][CH:26]=[CH:25][CH:24]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 219939451-Tert-butoxycarbonyl-1'-(3-phenylpropan-1-yl)-4,4'-bipiperidine

Product 1

HCID 21993863HCID 21993863, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 20 ml of methanol was dissolved 3.425 g (8.860 mM) of 1-tert-butoxycarbonyl-1′-(3-phenylpropan-1-yl)-4,4′-bipiperidine, followed by addition of 5 ml of concentrated hydrochloric acid, and the mixture was stirred at room temperature for 6 hours. This reaction mixture was concentrated and crystallized from methanol-diethyl ether to provide the title compound.

Workup

  1. concentrationThis reaction mixture was concentrated
  2. customcrystallized from methanol-diethyl ether

Sources & evidence

ORD record
ord-c8733284518649afb86205a9ecedf7fb
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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