Hydrochloric Acid → HCID 21994184, compound

HRID 1978328Notes

Reaction equation

HRID 1978328 reaction equation
[Si]([O:8][CH2:9][C:10]1[CH:27]=[CH:26][CH:25]=[CH:24][C:11]=1[CH2:12][N:13]1[C:17](=[O:18])[C:16]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]2[C:14]1=[O:23])(C(C)(C)C)(C)C.Cl>CO.O.C(OCC)C>[OH:8][CH2:9][C:10]1[CH:27]=[CH:26][CH:25]=[CH:24][C:11]=1[CH2:12][N:13]1[C:17](=[O:18])[C:16]2=[CH:19][CH:20]=[CH:21][CH:22]=[C:15]2[C:14]1=[O:23]

Participants

5

Reactant 2

HCID 313Hydrochloric AcidHCID 21993862HCID 21993862, compound

Product 1

HCID 21994184HCID 21994184, compound

Reagents, catalysts & solvents 2

HCID 887MethanolSolventHCID 21584184Diethylether waterSolvent

Procedure

To a solution of 15.021 g (39.368 mM) of N-[2-(tert-butyldimethylsilyloxymethyl)benzyl]phthalimide in 50 ml of methanol was added 5 ml of concentrated hydrochloric acid at room temperature and the mixture was stirred at the prevailing temperature for 10 minutes. This reaction mixture was poured in water-diethyl ether and the resulting precipitate was recovered, rinsed serially with water and diethyl ether, and dried to provide the title compound.

Workup

  1. customthe resulting precipitate was recovered
  2. washrinsed serially with water and diethyl ether
  3. customdried

Sources & evidence

ORD record
ord-29be54d9a4bb4759af1b915bdc1d5f19
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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