Hydrochloric Acid → HCID 21994199, compound

HRID 1978332Notes

Reaction equation

HRID 1978332 reaction equation
[C:1]1([CH:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH:14]3[CH2:19][CH2:18][N:17](C(OC(C)(C)C)=O)[CH2:16][CH2:15]3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:27]>CO>[ClH:27].[ClH:27].[C:1]1([CH:7]2[CH2:12][CH2:11][N:10]([CH2:13][CH:14]3[CH2:19][CH2:18][NH:17][CH2:16][CH2:15]3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21994100HCID 21994100, compound

Product 1

HCID 21994199HCID 21994199, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

To a solution of 3.550 g (9.902 mM) of tert-butyl 4-(4-phenylpiperidinomethyl)piperidine-1-carboxylate in 30 ml of methanol was added 5 ml of concentrated hydrochloric acid and the mixture was stirred at room temperature for 3 hours. The solvent was then distilled off and the residue was crystallized from ethanol-diethyl ether to provide the title compound.

Workup

  1. distillationThe solvent was then distilled off
  2. customthe residue was crystallized from ethanol-diethyl ether

Sources & evidence

ORD record
ord-c07c360af7264e0fb5f8d94bcaccc3be
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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