Formamide → HCID 21994064, compound

HRID 1978384Notes

Reaction equation

HRID 1978384 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4](F)[N:3]=1.O.C(OCC)(=O)C.[CH:16]([NH2:18])=[O:17]>>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[C:4]([NH:18][CH:16]=[O:17])[N:3]=1

Participants

5

Reactant 4

HCID 713FormamideHCID 962WaterHCID 8857Ethyl AcetateHCID 739342,6-Difluoropyridine

Product 1

HCID 21994064HCID 21994064, compound

Procedure

A solution of 0.63 g of 2,6-difluoropyridine in 0.2 mL of formamide was stirred for 3 hours at 150° C. The reaction mixture was cooled to room temperature, to which were added water (100 mL) and ethyl acetate (100 mL×3) for extraction. The extract solution was dried over anhydrous magnesium sulfate, followed by concentration to give powdery precipitate of 2-fluoro-6-(formylamino)pyridine. The powdery product was collected by filtration and dried for 2 hours at 40° C. under reduced pressure (0.4 g).

Workup

  1. extractionfor extraction
  2. dry with materialThe extract solution was dried over anhydrous magnesium sulfate
  3. concentrationfollowed by concentration

Sources & evidence

ORD record
ord-a4c247602d1c4bc3bae2c1adc436f19b
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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