Hydrochloric Acid → HCID 21994023, compound

HRID 1978477Notes

Reaction equation

HRID 1978477 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([CH:18]2[S:28][C:27]3[N:29]4[C:20](=[CH:21][N:22]=[C:23]4[CH:24]=[CH:25][CH:26]=3)[CH2:19]2)=[O:17])[CH2:10][CH2:9]1)=O)(C)(C)C.[ClH:30]>CC(O)C>[ClH:30].[ClH:30].[NH:8]1[CH2:13][CH2:12][CH:11]([CH2:14][NH:15][C:16]([CH:18]2[S:28][C:27]3[N:29]4[C:20](=[CH:21][N:22]=[C:23]4[CH:24]=[CH:25][CH:26]=3)[CH2:19]2)=[O:17])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21993761HCID 21993761, compound

Product 1

HCID 21994023HCID 21994023, compoundYield 90.2%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

To a solution of 480 g (1.15 mM) of N-[(1-tert-butoxycarbonyl-4-piperidyl)methyl]-3,4-dihydro-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in 20 ml of 2-propanol was added 0.47 ml (5.76 mM) of 12N-hydrochloric acid and the mixture was stirred at room temperature for 1 hours. This reaction mixture was concentrated under reduced pressure and the resulting crystals were collected by filtration and rinsed with a small amount of ether to provide 404 mg (90.2%) of the title compound as white crystals.

Workup

  1. concentrationThis reaction mixture was concentrated under reduced pressure
  2. filtrationthe resulting crystals were collected by filtration
  3. washrinsed with a small amount of ether

Sources & evidence

ORD record
ord-3c3384e595be4ae9810b19a897e41937
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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