反应详情

To a solution of 437.4 mg (1.01 mM) of N-[1-(4-phenylbutan-1-yl)piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (10 ml) was added 0.5 ml (6 mM) of 12N-hydrochloric acid and the mixture was stirred at room temperature for 16 hours. After this reaction mixture was concentrated, a small amount of ethanol was added to the residue and the crystals were collected by filtration and rinsed with ethanol and diethyl ether to provide the title compound as orange-colored crystals.

1. concentrationAfter this reaction mixture was concentrated
2. additiona small amount of ethanol was added to the residue
3. filtrationthe crystals were collected by filtration
4. washrinsed with ethanol and diethyl ether