Hydrochloric Acid → HCID 21993720, compound

HRID 1978486Notes

Reaction equation

HRID 1978486 reaction equation
[C:1]1([CH:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:35]=[CH:34][C:17]([CH2:18][NH:19][C:20]([C:22]4[S:32][C:31]5[N:33]6[C:24](=[CH:25][N:26]=[C:27]6[CH:28]=[CH:29][CH:30]=5)[CH:23]=4)=[O:21])=[CH:16][CH:15]=3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1.[ClH:36]>C(O)C>[ClH:36].[ClH:36].[C:1]1([CH:7]2[CH2:12][CH2:11][N:10]([CH2:13][C:14]3[CH:15]=[CH:16][C:17]([CH2:18][NH:19][C:20]([C:22]4[S:32][C:31]5[N:33]6[C:24](=[CH:25][N:26]=[C:27]6[CH:28]=[CH:29][CH:30]=5)[CH:23]=4)=[O:21])=[CH:34][CH:35]=3)[CH2:9][CH2:8]2)[CH:6]=[CH:5][CH:4]=[CH:3][CH:2]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21993721HCID 21993721, compound

Product 1

HCID 21993720HCID 21993720, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1.59 g (3.31 mM) of N-[4-(4-phenylpiperidin-1-ylmethyl)benzyl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol was added 1 ml (12 mM) of 12N-hydrochloric acid at room temperature, and the mixture was stirred for several minutes. This reaction mixture was concentrated and, after addition of ethanol and diethyl ether, the crystal crop was harvested by filtration and rinsed with ethanol and diethyl ether to provide the title compound as orange-colored crystals.

Workup

  1. concentrationThis reaction mixture was concentrated
  2. additionafter addition of ethanol and diethyl ether
  3. filtrationthe crystal crop was harvested by filtration
  4. washrinsed with ethanol and diethyl ether

Sources & evidence

ORD record
ord-406e9b6512364de0aa5533e8d8737e23
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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