Hydrochloric Acid → HCID 21993654, compound

HRID 1978518Notes

Reaction equation

HRID 1978518 reaction equation
[C:1]([N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]([C:22]2[S:32][C:31]3[N:33]4[C:24](=[CH:25][N:26]=[C:27]4[CH:28]=[CH:29][CH:30]=3)[CH:23]=2)=[O:21])[CH2:11][CH2:10]1)(=[O:8])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[ClH:34]>C(O)C>[ClH:34].[ClH:34].[C:1]([N:9]1[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][CH2:18][NH:19][C:20]([C:22]2[S:32][C:31]3[N:33]4[C:24](=[CH:25][N:26]=[C:27]4[CH:28]=[CH:29][CH:30]=3)[CH:23]=2)=[O:21])[CH2:11][CH2:10]1)(=[O:8])[C:2]1[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21993655HCID 21993655, compound

Product 1

HCID 21993654HCID 21993654, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 1.16 g (2.51 mmol.) of N-[4-(4-benzoylpiperazin-1-yl)butan-1-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol was added, at room temperature, 1 ml (12 mmol.) of 12N hydrochloric acid. The mixture was stirred for several minutes. The resulting crystals were collected by filtration and washed with ethanol and diethyl ether to give the object compound as orange crystals. The yield was 0.918 g (69%).

Workup

  1. filtrationThe resulting crystals were collected by filtration
  2. washwashed with ethanol and diethyl ether

Sources & evidence

ORD record
ord-7eb4d8ffe55a4b9cb9efd5605beecc3f
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

Loading…