Hydrochloric Acid → HCID 21994149, compound

HRID 1978523Notes

Reaction equation

HRID 1978523 reaction equation
[CH2:1]([O:3][C:4]([C:6]1[CH:36]=[CH:35][C:9]([O:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([NH:20][C:21]([C:23]3[S:33][C:32]4[N:34]5[C:25](=[CH:26][N:27]=[C:28]5[CH:29]=[CH:30][CH:31]=4)[CH:24]=3)=[O:22])[CH2:16][CH2:15]2)=[CH:8][CH:7]=1)=[O:5])[CH3:2].[ClH:37]>C(O)C>[ClH:37].[ClH:37].[CH2:1]([O:3][C:4]([C:6]1[CH:36]=[CH:35][C:9]([O:10][CH2:11][CH2:12][CH2:13][N:14]2[CH2:19][CH2:18][CH:17]([NH:20][C:21]([C:23]3[S:33][C:32]4[N:34]5[C:25](=[CH:26][N:27]=[C:28]5[CH:29]=[CH:30][CH:31]=4)[CH:24]=3)=[O:22])[CH2:16][CH2:15]2)=[CH:8][CH:7]=1)=[O:5])[CH3:2]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21994143HCID 21994143, compound

Product 1

HCID 21994149HCID 21994149, compoundYield 98.2%

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

To a solution of 329.7 mg (0.65 mmol.) of N-[1-[3-(4-ethoxycarbonylphenoxy)propan-1-yl]piperidin-4-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide in ethanol (5 ml) was added, at room temperature, 2 ml (24 mmol.) of 12N hydrochloric acid. The mixture was stirred for one hour. The resulting crystalline precipitate was collected by filtration, followed by washing with ethanol and diethyl ether to afford the object compound (369.8 mg, 98%) as orange crystals.

Workup

  1. filtrationThe resulting crystalline precipitate was collected by filtration
  2. washby washing with ethanol and diethyl ether

Sources & evidence

ORD record
ord-a4651aed20d440338438116c31c71ee8
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

Loading…