Hydrochloric Acid → HCID 21993645, compound

HRID 1978536Notes

Reaction equation

HRID 1978536 reaction equation
[ClH:1].[C:2]1([CH2:8][N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]3[S:31][C:30]4[N:32]5[C:23](=[CH:24][N:25]=[C:26]5[CH:27]=[CH:28][CH:29]=4)[CH:22]=3)=[O:20])[C:11](=[O:33])[CH2:10]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C>[ClH:1].[ClH:1].[C:2]1([CH2:8][N:9]2[CH2:14][CH2:13][N:12]([CH2:15][CH2:16][CH2:17][NH:18][C:19]([C:21]3[S:31][C:30]4[N:32]5[C:23](=[CH:24][N:25]=[C:26]5[CH:27]=[CH:28][CH:29]=4)[CH:22]=3)=[O:20])[C:11](=[O:33])[CH2:10]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21993643HCID 21993643, compound

Product 1

HCID 21993645HCID 21993645, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid(0.8 ml) was added to a stirred solution of N-[3-(4-phenylmethyl-2-oxopiperazin-1-yl)propan-1-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide (300 mg, 0.670 mmol) in ethanol (5.0 ml) at room temperature. After stirring at room temperature for 1 hour, the reaction mixture was concentrated in vacuo to give N-(3-(4-phenylmethyl-2-oxopiperazin-1-yl)propan-1-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride as an orange amorphous powder (345 mg, 98%).

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-cad0fbe1ae3546d0be8ce927d5178f56
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

Loading…