Hydrochloric Acid → HCID 21994098, compound

HRID 1978538Notes

Reaction equation

HRID 1978538 reaction equation
[ClH:1].[C:2]1([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][NH:19][C:20]([C:22]3[S:32][C:31]4[N:33]5[C:24](=[CH:25][N:26]=[C:27]5[CH:28]=[CH:29][CH:30]=4)[CH:23]=3)=[O:21])[C:12](=[O:34])[CH2:11]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C>[ClH:1].[ClH:1].[C:2]1([CH2:8][CH2:9][N:10]2[CH2:15][CH2:14][N:13]([CH2:16][CH2:17][CH2:18][NH:19][C:20]([C:22]3[S:32][C:31]4[N:33]5[C:24](=[CH:25][N:26]=[C:27]5[CH:28]=[CH:29][CH:30]=4)[CH:23]=3)=[O:21])[C:12](=[O:34])[CH2:11]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21994029HCID 21994029, compound

Product 1

HCID 21994098HCID 21994098, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (0.8 ml) was added to a stirred solution of N-[3-[4-(2-phenylethan-1-yl)-2-oxopiperazin-1-yl]propan-1-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide (369 mg, 0.799 mmol) in ethanol (5.0 ml) at room temperature. After stirring at room temperature for 1 hour, the reaction mixture was concentrated in vacuo to give N-[3-[4-(2-phenylethan-1-yl)2-oxopiperazin-1-yl]propan-1-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride as an orange amorphous powder (424 mg, 99%).

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-3ad26bb0286f46fb8ff20b0cce4b5718
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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