Hydrochloric Acid → HCID 21993931, compound

HRID 1978540Notes

Reaction equation

HRID 1978540 reaction equation
[ClH:1].[C:2]1([CH2:8][CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][NH:20][C:21]([C:23]3[S:33][C:32]4[N:34]5[C:25](=[CH:26][N:27]=[C:28]5[CH:29]=[CH:30][CH:31]=4)[CH:24]=3)=[O:22])[C:13](=[O:35])[CH2:12]2)[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1>C(O)C>[ClH:1].[ClH:1].[C:2]1([CH2:8][CH2:9][CH2:10][N:11]2[CH2:16][CH2:15][N:14]([CH2:17][CH2:18][CH2:19][NH:20][C:21]([C:23]3[S:33][C:32]4[N:34]5[C:25](=[CH:26][N:27]=[C:28]5[CH:29]=[CH:30][CH:31]=4)[CH:24]=3)=[O:22])[C:13](=[O:35])[CH2:12]2)[CH:3]=[CH:4][CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21993932HCID 21993932, compound

Product 1

HCID 21993931HCID 21993931, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Concentrated hydrochloric acid (0.8 ml) was added to a stirred solution of N-[3-[4-(3-phenylpropan-1-yl)-2-oxopiperazin-1-yl]propan-1-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide (261 mg, 0.549 mmol) in ethanol (5.0 ml) at room temperature. After stirring at room temperature for 1 hour, the reaction mixture was concentrated in vacuo to give N-[3-[4-(3-phenylpropan-1-yl)-2-oxopiperazin-1-yl]propan-1-yl]-5-thia-1,8b-diazaacenaphthylene-4-carboxamide dihydrochloride as an orange amorphous powder(295 mg, 98%).

Workup

  1. concentrationthe reaction mixture was concentrated in vacuo

Sources & evidence

ORD record
ord-c8a529cddf704fe8bb0756cc15ee9db7
Source dataset
uspto-grants-2001_05
Patent number
US06235731B1

Reaction notes

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