反应详情

To a solution of 6-methoxybenzofuran (16.9 g) in collidine (200 ml) was added lithium iodide (30.5 g), and the mixture was refluxed under argon atmosphere for 1 day and cooled. To the mixture was added 1N hydrochloric acid, and the mixture was extracted with ethyl acetate. The organic layer was washed with 2N hydrochloric acid (5 times) and then washed with water and saturated brine, and dried with magnesium sulfate. Under reduced pressure, the solvent was evaporated, and the residue was purified with silica gel column chromatography to give dark brown oil of 6-hydroxybenzofuran (2.9 g).

1. temperaturethe mixture was refluxed under argon atmosphere for 1 day
2. temperaturecooled
3. extractionthe mixture was extracted with ethyl acetate
4. washThe organic layer was washed with 2N hydrochloric acid (5 times)
5. washwashed with water and saturated brine
6. dry with materialdried with magnesium sulfate
7. customUnder reduced pressure, the solvent was evaporated
8. customthe residue was purified with silica gel column chromatography