Water → HCID 70231562, compound

HRID 1978846Notes

Reaction equation

HRID 1978846 reaction equation
[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:17])[F:16])[N:10]([CH3:19])[C:9]2=[O:20])=[CH:4][C:3]=1[CH:21]=O.[C:23]([CH2:25]P(=O)(OCC)OCC)#[N:24].C(=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[Cl:1][C:2]1[CH:7]=[CH:6][C:5]([N:8]2[C:13](=[O:14])[CH:12]=[C:11]([C:15]([F:18])([F:16])[F:17])[N:10]([CH3:19])[C:9]2=[O:20])=[CH:4][C:3]=1[CH:21]=[CH:25][C:23]#[N:24]

Participants

6

Reactant 4

HCID 962WaterHCID 11430Potassium CarbonateHCID 75676Diethyl (cyanomethyl)phosphonateHCID 212012252-Chloro-5-[3,6-dihydro-2,6-dioxo-3-methyl-4-trifluoromethyl-1(2H)-pyrimidinyl]benzaldehyde

Product 1

HCID 70231562HCID 70231562, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Procedure

3.3 g of 3-(4-chloro-3-formylphenyl)-2,4-dioxo-1-methyl-6-trifluoromethyl-1,2,3,4-tetrahydropyrimidine in 30 ml of dimethylformamide were added dropwise to a suspension of 1.8 g of diethyl cyanomethylphosphonate and 1.5 g of potassium carbonate in 120 ml of dimethylformamide, and stirring was carried out for 20 hours at room temperature. Thereafter, 150 ml of water were added and the precipitate which had separated out was isolated, washed with water and petroleum ether and dried.

Workup

  1. customthe precipitate which had separated out
  2. customwas isolated
  3. washwashed with water and petroleum ether
  4. customdried

Sources & evidence

ORD record
ord-0fe3aea3a71046fca01771604e8146d9
Source dataset
uspto-grants-2001_05
Patent number
US06239074B1

Reaction notes

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