Water → HCID 86756861, compound

HRID 1978856Notes

Reaction equation

HRID 1978856 reaction equation
CI.[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:15](=[O:16])[C:14]3=[CH:17][S:18][CH:19]=[C:13]3[NH:12][C:11]2=[S:20])=[CH:6][C:5]=1[CH:21]=[C:22]([Cl:28])[C:23]([O:25][CH2:26][CH3:27])=[O:24].[C:29](=O)([O-])[O-].[K+].[K+].O>CN(C)C=O>[Cl:3][C:4]1[CH:9]=[CH:8][C:7]([N:10]2[C:15](=[O:16])[C:14]3=[CH:17][S:18][CH:19]=[C:13]3[N:12]=[C:11]2[S:20][CH3:29])=[CH:6][C:5]=1[CH:21]=[C:22]([Cl:28])[C:23]([O:25][CH2:26][CH3:27])=[O:24]

Participants

6

Reactant 4

HCID 962WaterHCID 6328Methyl iodideHCID 11430Potassium CarbonateHCID 86756862HCID 86756862, compound

Product 1

HCID 86756861HCID 86756861, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent2×

Conditions

Temperature
10 °C

Procedure

0.28 g of methyl iodide in 5 ml of dimethylformamide was added to a solution of 0.8 g of 3-[4-chloro-3-(2-chloro-2-ethoxycarbonylethenyl)-phenyl]-4-oxo-2-thioxo-1,2,3,4-tetrahydrothieno[3,4-d]pyrimidine and 0.27 g of potassium carbonate in 40 ml of dimethylformamide. Stirring was carried out for 2 days, after which the mixture was cooled to 10° C., 80 ml of water were added and stirring was effected for a further 2 hours. The resulting precipitate was removed, washed with water and dried.

Workup

  1. stirringstirring
  2. waitwas effected for a further 2 hours
  3. customThe resulting precipitate was removed
  4. washwashed with water
  5. customdried

Sources & evidence

ORD record
ord-79905d38ff814750a9b1e3d921c25961
Source dataset
uspto-grants-2001_05
Patent number
US06239074B1

Reaction notes

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