Water → HCID 69955337, compound

HRID 1978915Notes

Reaction equation

HRID 1978915 reaction equation
[CH3:1][C:2]1[N:11]([N:12]2[C:24](=[O:25])[C:22]3[C:23]4[N:15]([C:16]([O:26][CH3:27])=[CH:17][C:18]=4[CH2:19][CH2:20][CH:21]=3)[C:14]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[CH:13]2)[C:10](=[O:34])[C:9]2[C:4](=[CH:5][C:6]([C:35]([O:37]C)=[O:36])=[CH:7][CH:8]=2)[N:3]=1.O.[OH-].[K+]>C1COCC1>[CH3:1][C:2]1[N:11]([N:12]2[C:24](=[O:25])[C:22]3[C:23]4[N:15]([C:16]([O:26][CH3:27])=[CH:17][C:18]=4[CH2:19][CH2:20][CH:21]=3)[C:14]([C:28]3[CH:33]=[CH:32][CH:31]=[CH:30][CH:29]=3)=[CH:13]2)[C:10](=[O:34])[C:9]2[C:4](=[CH:5][C:6]([C:35]([OH:37])=[O:36])=[CH:7][CH:8]=2)[N:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 14797Potassium HydroxideHCID 69955363HCID 69955363, compound

Product 1

HCID 69955337HCID 69955337, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Conditions

Temperature
22.5 °C

Procedure

1.3 g of product of Example 2B (2.55 mmol) are dissolved in 55 ml of THF, 18 ml of water containing 0.33 g of potassium hydroxide are added and the mixture is stirred at 20-25° C. for 5 h. Ice is added and the mixture is acidified to pH=5. It is extracted with CH2Cl2. The extracts are purified by chromatography. 0.55 g obtained. Yld: 44%. Decomposition starting at 225° C.—TLC (DM5): Rf=0.1.

Workup

  1. additionIce is added
  2. extractionIt is extracted with CH2Cl2
  3. customThe extracts are purified by chromatography
  4. custom0.55 g obtained
  5. customstarting at 225° C.

Sources & evidence

ORD record
ord-82ada562f72e453c90c0675fd5f32567
Source dataset
uspto-grants-2001_05
Patent number
US06239130B1

Reaction notes

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