4-(4'-Methyl-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester → 4-(4'-Methyl-biphenyl-4-yl)-4-oxo-butyric acid

HRID 1979155Notes

Reaction equation

HRID 1979155 reaction equation
[CH3:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:21])[CH2:15][CH2:16][C:17]([O:19]C)=[O:18])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1>Cl>[CH3:1][C:2]1[CH:3]=[CH:4][C:5]([C:8]2[CH:13]=[CH:12][C:11]([C:14](=[O:21])[CH2:15][CH2:16][C:17]([OH:19])=[O:18])=[CH:10][CH:9]=2)=[CH:6][CH:7]=1

Participants

3

Reactant 1

HCID 702115634-(4'-Methyl-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester

Product 1

HCID 141166664-(4'-Methyl-biphenyl-4-yl)-4-oxo-butyric acidYield 97.1%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

In a manner similar to Example 4, Step (b), 4-(4′-methyl-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester (1.21 g, 0.0043 mol) was refluxed in 6 M aqueous hydrochloric acid to give 1.12 g of 4-(4′-methyl-biphenyl-4-yl)-4-oxo-butyric acid as an off-white solid; mp 183-186° C.

Sources & evidence

ORD record
ord-4eb2ac9da9ee4be18e1ce109d49e32d7
Source dataset
uspto-grants-2001_05
Patent number
US06239288B1

Reaction notes

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