4-(3',4'-Dichloro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester → 4-(3',4'-Dichloro-4-biphenylyl)-4-oxo-butyric acid

HRID 1979177Notes

Reaction equation

HRID 1979177 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:14]=[CH:13][C:12]([C:15](=[O:22])[CH2:16][CH2:17][C:18]([O:20]C)=[O:19])=[CH:11][CH:10]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]>Cl>[Cl:1][C:2]1[CH:3]=[C:4]([C:9]2[CH:10]=[CH:11][C:12]([C:15](=[O:22])[CH2:16][CH2:17][C:18]([OH:20])=[O:19])=[CH:13][CH:14]=2)[CH:5]=[CH:6][C:7]=1[Cl:8]

Participants

3

Reactant 1

HCID 865835194-(3',4'-Dichloro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester

Product 1

HCID 183641344-(3',4'-Dichloro-4-biphenylyl)-4-oxo-butyric acidYield 98.2%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

In a manner similar to Example 4, Step (b), 4-(3′,4′-dichloro-biphenyl-4-yl)-4-oxo-butyric acid, methyl ester (1.360 g, 0.004033 mol) was refluxed in 6 M aqueous hydrochloric acid (25 mL) to give 1.280 g of 4-(3′,4′-dichloro-biphenyl-4-yl)-4-oxo-butyric acid as a white solid; mp 154-156° C.

Sources & evidence

ORD record
ord-c2a639c8107f460fa2ebded1f48cfbf7
Source dataset
uspto-grants-2001_05
Patent number
US06239288B1

Reaction notes

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