Sodium Hydroxide → HCID 20439398, compound

HRID 1979535Notes

Reaction equation

HRID 1979535 reaction equation
C(O)(=O)C(O)=[O:3].C(O)(=O)C(O)=O.[CH3:13][N:14]1[C:18]([NH:19][CH2:20][CH2:21][CH2:22][O:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([CH2:30][N:31]3[CH2:36][CH2:35][CH2:34][CH2:33][CH2:32]3)[CH:25]=2)=[N:17][N:16]=[C:15]1[CH2:37][C:38]#[N:39].[OH-].[Na+]>Cl>[CH3:13][N:14]1[C:18]([NH:19][CH2:20][CH2:21][CH2:22][O:23][C:24]2[CH:29]=[CH:28][CH:27]=[C:26]([CH2:30][N:31]3[CH2:32][CH2:33][CH2:34][CH2:35][CH2:36]3)[CH:25]=2)=[N:17][N:16]=[C:15]1[CH2:37][C:38]([NH2:39])=[O:3]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 86739751HCID 86739751, compound

Product 1

HCID 20439398HCID 20439398, compoundYield 28.4%

Reagents, catalysts & solvents 1

HCID 313Hydrochloric AcidSolvent

Procedure

A solution of 4-methyl-5-[[3-[3-(1-piperidinylmethyl)phenoxy]propyl]amino]-4H-1,2,4-triazole-3-acetonitrile dioxalate (0.05 g) in 35% hydrochloric acid (1 ml) was heated at 40° C. for 3 h. The mixture was basified with sodium hydroxide and extracted with chloroform. Evaporation of the organic solution gave the title compound (0.01 g) as a white powder.

Workup

  1. extractionextracted with chloroform
  2. customEvaporation of the organic solution

Sources & evidence

ORD record
ord-186d1e8d016d42fe8f4e9c89e2c40319
Source dataset
uspto-grants-1984_11
Patent number
US04481199

Reaction notes

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