Hydrazine hydrate (1:1) → HCID 20439483, compound

HRID 1979608Notes

Reaction equation

HRID 1979608 reaction equation
Cl[C:2]1[N:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].O.[NH2:13][NH2:14]>>[NH:13]([C:2]1[N:10]=[C:9]([CH3:11])[CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])[NH2:14]

Participants

3

Reactant 2

HCID 24654Hydrazine hydrate (1:1)HCID 1217242-Chloro-6-methylnicotinic acid

Product 1

HCID 20439483HCID 20439483, compoundYield 50%

Procedure

2-Chloro-6-methyl nicotinic acid (3.5 g, 0.02 m) was refluxed with hydrazine hydrate (5 ml) and absolute alcohol (20 ml) for 5 hours. The solid was separated, washed with alcohol and crystallised from water to yield 50% of 2-hydrazino-6-methylnicotinic acid.

Workup

  1. customThe solid was separated
  2. washwashed with alcohol
  3. customcrystallised from water

Sources & evidence

ORD record
ord-3bdfdccd29824b53b0c634bf0c49270d
Source dataset
uspto-grants-1984_11
Patent number
US04481268

Reaction notes

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