Hydrochloric Acid → HCID 12899415, compound

HRID 1979760Notes

Reaction equation

HRID 1979760 reaction equation
[Br:1][C:2]1[CH:3]=[CH:4][C:5]([O:13]C(=O)C)=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2.Cl>>[Br:1][C:2]1[CH:3]=[CH:4][C:5]([OH:13])=[C:6]2[C:11]=1[NH:10][C:9](=[O:12])[CH2:8][CH2:7]2

Participants

3

Reactant 2

HCID 313Hydrochloric AcidHCID 12899414HCID 12899414, compound

Product 1

HCID 12899415HCID 12899415, compound

Procedure

Then 21 g of thus obtained 8-bromo-5-acetyloxy-3,4-dihydrocarbostyril was dispersed in 150 ml of 8N-hydrochloric acid and was heated under refluxing condition for 3 hours. After the reaction mixture was cooled, the insoluble matters were obtained by filtration, washed with water, dried and recrystallized from methanol-water. 14 Grams of 8-bromo-5-hydroxy-3,4-dihydrocarbostyril was obtained as in the form of colorless needle-like crystals. Melting point: 212°-213° C.

Workup

  1. temperaturewas heated
  2. temperatureunder refluxing condition for 3 hours
  3. temperatureAfter the reaction mixture was cooled
  4. customthe insoluble matters were obtained by filtration
  5. washwashed with water
  6. customdried
  7. customrecrystallized from methanol-water

Sources & evidence

ORD record
ord-ac7c5097be2b4cf4a81424f8ea3b526a
Source dataset
uspto-grants-1984_11
Patent number
US04482560

Reaction notes

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