2-Chlorobenzaldehyde → HCID 56616910, compound

HRID 1979801Notes

Reaction equation

HRID 1979801 reaction equation
[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=O.[NH2:10][CH2:11][P:12]([C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1)[C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1.C([O:28]C(C)C)(C)C>C(O)C>[Cl:1][C:2]1[CH:9]=[CH:8][CH:7]=[CH:6][C:3]=1[CH:4]=[N:10][CH2:11][P:12](=[O:28])([C:13]1[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

5

Reactant 3

HCID 69962-ChlorobenzaldehydeHCID 7914Diisopropyl EtherHCID 20439053HCID 20439053, compound

Product 1

HCID 56616910HCID 56616910, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent2×

Conditions

Temperature
50 °C

Procedure

2.18 g. (0.015 mol) o-chlorobenzaldehyde is added dropwise to a solution of 3.5 g. (0.015 mol) aminomethyldiphenylphosphine in 150 ml. ethanol at ambient temperature. After evaporation of the solvent by heating to 50° C. under a slight vacuum, a clear yellow oil is obtained which is taken up hot in 50 ml. of a mixture of diisopropyl ether and ethanol (25/1 v/v). After cooling to 10° C., filtering and drying at 40° C. in vacuo, there are obtained 4.9 g. of crystals of the desired product; m.p. 89° C.

Workup

  1. customat ambient temperature
  2. customAfter evaporation of the solvent
  3. customa clear yellow oil is obtained which
  4. temperatureAfter cooling to 10° C.
  5. filtrationfiltering
  6. customdrying at 40° C. in vacuo, there
  7. customare obtained 4.9 g

Sources & evidence

ORD record
ord-a2787c4a073446309247945ac01731eb
Source dataset
uspto-grants-1984_11
Patent number
US04482718

Reaction notes

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