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HRID1979965

反应详情

EQUATION

反应方程式

HRID 1979965 的结构方程式

REACTANTS

反应物

4
结构：CN(C)C=O
HCID6228

N,N-Dimethylformamide

C3H7NO

2 次

结构：CCN(CC)CC
HCID8471

Triethylamine

C6H15N

结构：[Br-].[Na+]
HCID253881

Sodium bromide

BrNa

结构：CC(C)(C)OC(=O)NC[C@H]1CC[C@H](C(=O)O)CC1
HCID178453624

未命名化合物

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)NC[C@H]1CC[C@H](C(=O)O)CC1.CC(C)(C)OC(=O)NC[C@H]1CC[C@H](C(=O)O)CC1.CN(C)C(=O)C(O)O
HCID178453625

未命名化合物

PROCEDURE

实验过程

Sodium bromide (10.2 g; 0.1 mol) and 1,1-dichloro-N,N-dimethylacetamide (7.8 g; 0.05 mol) was added to dry dimethylformamide (100 ml) and the mixture was stirred for 4 h. Triethylamine (20.7 g; 0.2 mol) and trans-4-(tert.-butyloxycarbonylaminomethyl)cyclohexanecarboxylic acid (25.7 g; 0.1 mol) dissolved in dimethylformamide was added. The mixture was stirred for 84 h at 50° C. The solvent was evaporated and the residue was taken up into diethylether and washed, dried and evaporated. The oily residue was stirred with pentane. Yield 7 g, m.p. 110° C.

WORKUP

后处理

  1. additionwas added
  2. stirringThe mixture was stirred for 84 h at 50° C
  3. customThe solvent was evaporated
  4. washwashed
  5. customdried
  6. customevaporated
  7. stirringThe oily residue was stirred with pentane