Methyl iodide → HCID 13477859, compound

HRID 1980215Notes

Reaction equation

HRID 1980215 reaction equation
[F:1][C:2]([F:24])([F:23])[CH2:3][O:4][C:5]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:6]=1[CH2:7][S:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N+:12]=1[O-:17])(=[O:10])=[O:9].[H-].[Na+].[CH3:27]I>CN(C)C=O>[F:24][C:2]([F:1])([F:23])[CH2:3][O:4][C:5]1[CH:21]=[CH:20][C:19]([Cl:22])=[CH:18][C:6]=1[CH:7]([S:8]([C:11]1[CH:16]=[CH:15][CH:14]=[CH:13][N+:12]=1[O-:17])(=[O:9])=[O:10])[CH3:27]

Participants

5

Reactant 3

HCID 6328Methyl iodideHCID 24758Sodium hydrideHCID 20402343HCID 20402343, compound

Product 1

HCID 13477859HCID 13477859, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

In the same manner as Example 1, 2.00 g of 2-[2-(2,2,2-trifluoroethoxy)-5-chlorobenzylsulfonyl]pyridine-N-oxide, 230 mg of 55% sodium hydride and 740 mg of methyl iodide were mixed with 50 ml of dimethylformamide and the mixture was reacted, followed by the same after-treatment as in Example 1, whereby 1.43 g of Compound No. 27 of the present invention was obtained. The product was white crystals having a melting point of from 119° to 121° C.

Workup

  1. customthe mixture was reacted
  2. custom27 of the present invention was obtained
  3. customof from 119° to 121° C.

Sources & evidence

ORD record
ord-8ab091b55ced4e678f555cc268be623b
Source dataset
uspto-grants-1985_04
Patent number
US04508561

Reaction notes

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