反应详情

4.25 g. (0.05 moles) of cyanoacetic acid are dissolved in 100 ml. of dichloromethane and a solution of 10.3 g. (0.05 moles) of dicyclohexylcarbodiimide and 9.2 g. (0.05 moles) of pentafluorophenol in 50 ml. of dichloromethane is added. The mixture is stirred at room temperature for 4 hours, cooled to 0° C. and the precipitated dicyclohecylcarbodiimide is removed by filtration, the solvent is removed by distillation and the residue is taken up in petrolether and the precipitated ester is filtered, trituated with petrolether, washed and dried.

1. temperaturecooled to 0° C.
2. customthe precipitated dicyclohecylcarbodiimide is removed by filtration
3. customthe solvent is removed by distillation
4. filtrationthe precipitated ester is filtered
5. washwashed
6. customdried