2,6-Difluorobenzoyl isocyanate → 1-(2,6-Difluorobenzoyl)-3-(6-methyl-5-phenyl-2-pyridyl)urea

HRID 1980321Notes

Reaction equation

HRID 1980321 reaction equation
[CH3:1][C:2]1[N:7]=[C:6]([NH2:8])[CH:5]=[CH:4][C:3]=1[C:9]1[CH:14]=[CH:13][CH:12]=[CH:11][CH:10]=1.[F:15][C:16]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:17]=1[C:18]([N:20]=[C:21]=[O:22])=[O:19]>C(OCC)(=O)C>[F:15][C:16]1[CH:26]=[CH:25][CH:24]=[C:23]([F:27])[C:17]=1[C:18]([NH:20][C:21]([NH:8][C:6]1[CH:5]=[CH:4][C:3]([C:9]2[CH:10]=[CH:11][CH:12]=[CH:13][CH:14]=2)=[C:2]([CH3:1])[N:7]=1)=[O:22])=[O:19]

Participants

4

Reactant 2

HCID 27333692,6-Difluorobenzoyl isocyanateHCID 135028556-Methyl-5-phenylpyridin-2-amine

Product 1

HCID 132426531-(2,6-Difluorobenzoyl)-3-(6-methyl-5-phenyl-2-pyridyl)urea

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

6-Methyl-5-phenyl-2-pyridylamine (500 mg) and 2,6-difluorobenzoyl isocyanate (650 mg) were reacted in 25 ml ethyl acetate. A precipitate formed which was filtered, dried, and identified as the desired product by NMR, m.p. 206°-208° C.

Workup

  1. customA precipitate formed which
  2. filtrationwas filtered
  3. customdried

Sources & evidence

ORD record
ord-8ff3a61095794189a178b61ee56fcf9f
Source dataset
uspto-grants-1985_04
Patent number
US04508722

Reaction notes

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