Propylamine → HCID 13336535, compound

HRID 1980495Notes

Reaction equation

HRID 1980495 reaction equation
[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1([CH2:18][N:19]2[CH:23]=[N:22][CH:21]=[N:20]2)[NH:13][CH:12]([C:14]([O:16]C)=O)[CH2:11][S:10]1.[CH2:24]([NH2:27])[CH2:25][CH3:26]>CO>[Cl:1][C:2]1[CH:7]=[C:6]([Cl:8])[CH:5]=[CH:4][C:3]=1[C:9]1([CH2:18][N:19]2[CH:23]=[N:22][CH:21]=[N:20]2)[NH:13][CH:12]([C:14]([NH:27][CH2:24][CH2:25][CH3:26])=[O:16])[CH2:11][S:10]1

Participants

4

Reactant 2

HCID 7852PropylamineHCID 13336534HCID 13336534, compound

Product 1

HCID 13336535HCID 13336535, compoundYield 39.9%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

1.87 g of 2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazole-1-yl methyl)-4-methoxycarbonyl thiazolidine (Compound No. 24) prepared in the same manner as in Working Example 2 and 3.0 g of n-propylamine were dissolved in 20 ml of methanol and reacted at a temperature of 60° C. for 1 hour. After distilling off methanol under reduced pressure, the reaction product was purified by silica gel column chromatography using a solvent mixture of chloroform and ethyl acetate as the developer, whereby 0.8 g of 2-(2,4-dichlorophenyl)-2-(1H-1,2,4-triazole-1-yl methyl)-4-(n-propylaminocarbonyl)thiazolidine (Compound No. 46 in Table 1) was obtained.

Workup

  1. customreacted at a temperature of 60° C. for 1 hour
  2. distillationAfter distilling off methanol under reduced pressure
  3. customthe reaction product was purified by silica gel column chromatography
  4. additiona solvent mixture of chloroform and ethyl acetate as the developer

Sources & evidence

ORD record
ord-1b30cb8d8028402aa3e4d675a4547247
Source dataset
uspto-grants-1985_04
Patent number
US04510154

Reaction notes

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