Hydrochloric Acid → HCID 178526577, compound

HRID 1980767Notes

Reaction equation

HRID 1980767 reaction equation
[N+:1]([C:4]1[CH:13]=[CH:12][CH:11]=[CH:10][C:5]=1[C:6]([NH:8][NH2:9])=[O:7])([O-:3])=[O:2].[C:14](=S)=[S:15].O.Cl>N1C=CC=CC=1>[SH:15][C:14]1[O:7][C:6]([C:5]2[CH:10]=[CH:11][CH:12]=[CH:13][C:4]=2[N+:1]([O-:3])=[O:2])=[N:8][N:9]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 6348Carbon DisulfideHCID 3781218o-Nitrobenzohydrazide

Product 1

HCID 178526577HCID 178526577, compound

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

The reactions of Equation 36 above can be run according to similar procedures described in E. Hogarth, J. Chem. Soc., 4811 (1952). Thus, in reaction 36a, 2-nitrobenzhydrazide XLVIII is reacted with carbon disulfide in pyridine solvent at 25° to 80° C. for about 4 to 16 hours, followed by addition of water and acidification with hydrochloric acid to form a 2-mercapto-5-(2-nitrophenyl)-1,3,4-oxadiazole of Formula (L). In reaction 36b, L is reacted with sodium hydroxide and methyl iodide in water at 0° to 30° C. for 0.2 to 1 hour to form Xk".

Sources & evidence

ORD record
ord-8c8f3f27092046e0b86780e68abe2712
Source dataset
uspto-grants-1985_04
Patent number
US04511392

Reaction notes

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