Methylamine → HCID 20400796, compound

HRID 1980857Notes

Reaction equation

HRID 1980857 reaction equation
C([O:3][C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([CH3:20])[C:12]=1[C:21]1[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=1)=O)C.[CH3:27][NH2:28]>C(O)CCC>[CH3:27][NH:28][C:4]([CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][C:11]1[C:19]2[C:14](=[CH:15][CH:16]=[CH:17][CH:18]=2)[N:13]([CH3:20])[C:12]=1[C:21]1[CH:22]=[N:23][CH:24]=[CH:25][CH:26]=1)=[O:3]

Participants

4

Reactant 2

HCID 6329MethylamineHCID 20400817HCID 20400817, compound

Product 1

HCID 20400796HCID 20400796, compound

Reagents, catalysts & solvents 1

HCID 2631-ButanolSolvent

Procedure

A solution of 4 g of 3-(5-ethoxycarbonylpentyl)-1-methyl-2-(3-pyridyl)indole in 40 ml of n-butanol is saturated with methylamine and heated on a steam bath in a pressure bottle for 3 days. The reaction mixture is evaporated to dryness and the product is crystallized from ethyl-ether to yield the 3-[5-(N-methylcarbamoyl)pentyl]-1-methyl-2-(3-pyridyl)indole.

Workup

  1. temperatureheated on a steam bath in a pressure bottle for 3 days
  2. customThe reaction mixture is evaporated to dryness
  3. customthe product is crystallized from ethyl-ether

Sources & evidence

ORD record
ord-0e808f1f383d4e7698d89f7dd74a36a9
Source dataset
uspto-grants-1985_04
Patent number
US04511573

Reaction notes

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