Water → 2-Amino-5-chloro-3-formyl-6-(n-propylamino)pyrazine

HRID 1981156Notes

Reaction equation

HRID 1981156 reaction equation
[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[N:6][C:5]([Cl:10])=[C:4](Cl)[N:3]=1.[CH2:12]([NH2:15])[CH2:13][CH3:14].O>C(O)(C)C>[NH2:1][C:2]1[C:7]([CH:8]=[O:9])=[N:6][C:5]([Cl:10])=[C:4]([NH:15][CH2:12][CH2:13][CH3:14])[N:3]=1

Participants

5

Reactant 3

HCID 962WaterHCID 7852PropylamineHCID 133678713-Amino-5,6-dichloropyrazine-2-carbaldehyde

Product 1

HCID 203998642-Amino-5-chloro-3-formyl-6-(n-propylamino)pyrazine

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

In 1.2 ml of isopropyl alcohol there was dissolved 2-amino-5,6-dichloro-3-formylpyrazine (0.095 g) 0.0005 M) prepared in Step B, after which n-propylamine (32 g; 0.042 ml; 0.00055 M) was added, and the reaction mixture was stirred at room temperature for 20.5 hours. When water was added to the reaction mixture, product precipitated, was filtered, and dried (23 mg). Additional product precipitated, was filtered, and dried (46 mg). The product was recrystallized from ethyl acetate/hexane. Elemental Analysis for C8H11N4OCl.

Workup

  1. customprepared in Step B
  2. customprecipitated
  3. filtrationwas filtered
  4. customdried (23 mg)
  5. customAdditional product precipitated
  6. filtrationwas filtered
  7. customdried (46 mg)
  8. customThe product was recrystallized from ethyl acetate/hexane

Sources & evidence

ORD record
ord-1956e11224004063aae464e43b823485
Source dataset
uspto-grants-1985_04
Patent number
US04512991

Reaction notes

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