Benzene → Proline benzyl ester

HRID 1981235Notes

Reaction equation

HRID 1981235 reaction equation
Cl.[NH:2]1[CH2:16][CH2:15][CH2:14][CH:3]1[C:4]([O:6][CH2:7][C:8]1[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1)=[O:5].C1C=CC=CC=1.C(N(CC)CC)C>O>[NH:2]1[CH2:16][CH2:15][CH2:14][CH:3]1[C:4]([O:6][CH2:7][C:8]1[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=1)=[O:5]

Participants

5

Reactant 3

HCID 241BenzeneHCID 8471TriethylamineHCID 308425616652-71-4

Product 1

HCID 99767Proline benzyl esterYield 103%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent2×

Conditions

Temperature
20 °C

Procedure

A mixture of 2.4 g of benzyl DL-prolinate hydrochloride, 25 ml of benzene, 5 ml of demineralized water and 1.01 g of triethylamine was stirred at 20° C. for one hour and the decanted organic phase was wahsed with water, dried and evaporated to dryness under reduced pressure to obtain 2.1 g of benzyl DL prolinate.

Workup

  1. customdried
  2. customevaporated to dryness under reduced pressure

Sources & evidence

ORD record
ord-7d1473eefdf140a4a12d09dcfc8ce6cd
Source dataset
uspto-grants-1985_04
Patent number
US04513139

Reaction notes

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