反应详情

温度

20 °C

To a 80% suspension of 0.28 mol of sodium hydride in dimethylformamide, 0.06 mol of 3-morpholinomethylphenol is added portionwise, under stirring at a temperature of about 20° C., then the mixture is stirred 15 minutes at room temperature and a solution of 0.08 mol of 3-chloropropylamine hydrochloride in 20 ml of dimethylformamide is added thereto at 5°-10° C. The reaction mixture is stirred 24 hours at room temperature, then, after addition of 400 ml of ice-water, it is extracted 4 times with 100 ml of ethyl acetate. The organic solution is washed twice with 30 ml of 10% sodium hydroxide, then 3 times with 20 ml of water. The mixture is dried over anhydrous sodium sulfate and evaporated to dryness under reduced pressure. Thus, 3-(3-morpholinomethylphenoxy)propylamine is obtained, in the form of a yellow oil. Yield: 64%.

1. stirringthe mixture is stirred 15 minutes at room temperature
2. customat 5°-10° C
3. stirringThe reaction mixture is stirred 24 hours at room temperature
4. extractionis extracted 4 times with 100 ml of ethyl acetate
5. washThe organic solution is washed twice with 30 ml of 10% sodium hydroxide
6. dry with materialThe mixture is dried over anhydrous sodium sulfate
7. customevaporated to dryness under reduced pressure