Diethyl Ether → 4-Amidino-2-benzoylphenol methanesulfonate

HRID 1981437Notes

Reaction equation

HRID 1981437 reaction equation
Cl.[C:2]([C:5]1[CH:10]=[CH:9][C:8]([OH:11])=[C:7]([C:12](=[O:19])[C:13]2[CH:18]=[CH:17][CH:16]=[CH:15][CH:14]=2)[CH:6]=1)(=[NH:4])[NH2:3].[CH3:20][S:21](O)(=[O:23])=[O:22].C(OCC)C>CO>[CH3:20][S:21]([O:11][C:8]1[CH:9]=[CH:10][C:5]([C:2](=[NH:3])[NH2:4])=[CH:6][C:7]=1[C:12](=[O:19])[C:13]1[CH:14]=[CH:15][CH:16]=[CH:17][CH:18]=1)(=[O:23])=[O:22]

Participants

5

Reactant 3

HCID 3283Diethyl EtherHCID 6395Methanesulfonic AcidHCID 135598740HCID 135598740, compound

Product 1

HCID 540991824-Amidino-2-benzoylphenol methanesulfonate

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

In 200 ml of methanol, was suspended the 4-amidino-2-benzoylphenol hydrochloride obtained above. To the suspension was added 60 g of methanesulfonic acid followed by ethyl ether. The precipitated pale yellow crystals were collected by filtration and dried to obtain 109 g of 4-amidino-2-benzoylphenol methanesulfonate.

Workup

  1. customobtained above
  2. filtrationThe precipitated pale yellow crystals were collected by filtration
  3. customdried

Sources & evidence

ORD record
ord-1e1056bd713c4b1dae1f0e2230923552
Source dataset
uspto-grants-1985_04
Patent number
US04514416

Reaction notes

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