Phosphorus oxychloride → HCID 23319695, compound

HRID 1981592Notes

Reaction equation

[Cl:1][C:2]1[C:3]2[C:4](=[C:9]([CH3:14])[S:10][C:11]=2[CH:12]=O)[N:5]=[C:6]([CH3:8])[CH:7]=1.Cl.[NH2:16]O.P(Cl)(Cl)(Cl)=O>>[Cl:1][C:2]1[C:3]2[C:4](=[C:9]([CH3:14])[S:10][C:11]=2[C:12]#[N:16])[N:5]=[C:6]([CH3:8])[CH:7]=1

Participants

Reactant 3

HCID 24813Phosphorus oxychloride

HCID 443297Hydroxyamine hydrochloride

HCID 23319701HCID 23319701, compound

Product 1

HCID 23319695HCID 23319695, compound

Procedure

4-Chloro-2,7-dimethylthieno[3,4-b]pyridine-5-carboxaldehyde is reacted with hydroxylamine hydrochloride and phosphoryl chloride by standard procedures to give 4-chloro-2,7-dimethylthieno[3,4-b]pyridine-5-carbonitrile.

Sources & evidence

ORD record: ord-fc258858510043ee83bbfb930f9350b1
Source dataset: uspto-grants-1986_06
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US04593099

Reaction notes

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