Hydrochloric Acid → HCID 13630972, compound

HRID 1981593Notes

Reaction equation

HRID 1981593 reaction equation
Cl[C:2]1[N:7]=[C:6]2[CH:8]=[CH:9][S:10][C:5]2=[CH:4][C:3]=1[C:11]#[N:12].[I-:13].[Na+].Cl.O>C(#N)C>[I:13][C:2]1[N:7]=[C:6]2[CH:8]=[CH:9][S:10][C:5]2=[CH:4][C:3]=1[C:11]#[N:12]

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 5238Sodium IodideHCID 13574649HCID 13574649, compound

Product 1

HCID 13630972HCID 13630972, compound

Reagents, catalysts & solvents 1

HCID 6342AcetonitrileSolvent

Procedure

A solution of 5 g of 5-chlorothieno[3,2-b]pyridine-6-carbonitrile, 10 g of sodium iodide and 1 ml of concentrated hydrochloric acid in 70 ml of acetonitrile was heated at reflux for 65 hours. The mixture was then poured into water and the resulting solid was separated by filtration. The solid was recrystallized from acetone to give 5-iodothieno[3,2-b]pyridine-6-carbonitrile as white needles melting at about 190°-191° C.

Workup

  1. temperatureat reflux for 65 hours
  2. customthe resulting solid was separated by filtration
  3. customThe solid was recrystallized from acetone

Sources & evidence

ORD record
ord-18f0fe7856354f238911d2c887c084e4
Source dataset
uspto-grants-1986_06
Patent number
US04593099

Reaction notes

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