Dichloromethane → HCID 23319717, compound

HRID 1981599Notes

Reaction equation

HRID 1981599 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:12]=[CH:13][CH:14]=1)[NH:5][CH:6]([CH3:11])[CH2:7][C:8]([OH:10])=O.[C:15](Cl)([Cl:17])=[O:16].C(Cl)Cl.[Cl-].[Al+3].[Cl-].[Cl-]>CN(C)C=O>[Cl:1][C:2]1[CH:3]=[C:4]2[C:12]([C:8](=[O:10])[CH2:7][CH:6]([CH3:11])[N:5]2[C:15]([Cl:17])=[O:16])=[CH:13][CH:14]=1

Participants

6

Reactant 4

HCID 6344DichloromethaneHCID 6371PhosgeneHCID 6451240Aluminum(III) ChlorideHCID 233197113-(3-Chloroanilino)butanoic acid

Product 1

HCID 23319717HCID 23319717, compound

Reagents, catalysts & solvents 1

HCID 6228DimethylformamideSolvent

Procedure

7-Chloro-1-chloroformyl-2-methyl-1,2,3,4-tetrahydro-4-quinolinone is prepared in a manner similar to that described in Example 5 but starting from 3-(3-chloroanilino)butanoic acid (5.42 g; 25.4 mmol), phosgene (6.7 g; 67.7 mmol), methylene chloride (25 cc), dimethylformamide (0.23 cc) and aluminum chloride (8.15 g; 61.1 mmol).

Sources & evidence

ORD record
ord-a4949f01f22c4e8ea890fa73bb318e24
Source dataset
uspto-grants-1986_06
Patent number
US04593101

Reaction notes

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