3-Chloroaniline → 3-(3-Chloroanilino)butanoic acid

HRID 1981600Notes

Reaction equation

HRID 1981600 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH2:5].[C:9]([OH:14])(=[O:13])/[CH:10]=[CH:11]/[CH3:12]>>[Cl:1][C:2]1[CH:3]=[C:4]([CH:6]=[CH:7][CH:8]=1)[NH:5][CH:11]([CH3:12])[CH2:10][C:9]([OH:14])=[O:13]

Participants

3

Reactant 2

HCID 79323-ChloroanilineHCID 637090Crotonic Acid

Product 1

HCID 233197113-(3-Chloroanilino)butanoic acid

Procedure

3-(3-Chloroanilino)butanoic acid is prepared in a manner similar to that described in Example 1, but starting from 3-chloroaniline (65 cc; 0.5 mol), crotonic acid (11.20 g; 0.129 mol) and distilled water (31 cc). After purification, a product (14.66 g; 68.6 mmol) is thus obtained in the form of a white powder which melts at about 50° C.

Workup

  1. distillationdistilled water (31 cc)
  2. customAfter purification
  3. customa product (14.66 g; 68.6 mmol) is thus obtained in the form of a white powder which melts at about 50° C.

Sources & evidence

ORD record
ord-f5568cbecb4d4b1cb1cda7ac947b2d4e
Source dataset
uspto-grants-1986_06
Patent number
US04593101

Reaction notes

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