反应详情

A mixture of N,N'-dibenzylethylenediamine (24.0 g., 0.1 mole), ethyl chloroacetate (V, 24.51 g., 0.2 mole), anhydrous sodium carbonate (10 g., 0.094 mole) in ethanol (250 ml.) is heated under reflux for 20 hours. The ethanol is removed under reduced pressure and the residue is partitioned between chloroform and water. Evaporation of the chloroform gives an oil which is dissolved in isopropanol (200 ml.) and acidified with ethereal hydrogen chloride. The precipitate of 1,4-bis(phenylmethyl)piperazinone hydrochloride is filtered off and recrystallized from isopropanol, m.p. 209°-212°.

1. temperatureis heated
2. temperatureunder reflux for 20 hours
3. customThe ethanol is removed under reduced pressure
4. customthe residue is partitioned between chloroform and water
5. customEvaporation of the chloroform
6. customgives an oil which
7. filtrationThe precipitate of 1,4-bis(phenylmethyl)piperazinone hydrochloride is filtered off
8. customrecrystallized from isopropanol, m.p. 209°-212°