Hydrochloric Acid → HCID 13040903, compound

HRID 1981652Notes

Reaction equation

HRID 1981652 reaction equation
[O:1]1[CH2:19][CH:2]1[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][C:13]([O:15][CH2:16][CH2:17][CH3:18])=[O:14])=[CH:7][CH:6]=1.[ClH:20].[CH:21]([NH2:24])([CH3:23])[CH3:22]>C(O)CC>[ClH:20].[OH:1][CH:2]([CH2:19][NH:24][CH:21]([CH3:23])[CH3:22])[CH2:3][O:4][C:5]1[CH:10]=[CH:9][C:8]([CH2:11][CH2:12][C:13]([O:15][CH2:16][CH2:17][CH3:18])=[O:14])=[CH:7][CH:6]=1

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 6363IsopropylamineHCID 13137383HCID 13137383, compound

Product 1

HCID 13040903HCID 13040903, compoundYield 56%

Reagents, catalysts & solvents 1

HCID 10311-PropanolSolvent2×

Procedure

A solution of 1.5 g (0.006 mole) of n-propyl 3-[4-(2,3-epoxypropoxy)phenyl]propionate in 10 mL of isopropylamine and 20 mL of n-propanol was heated to reflux for 4 hours. The reaction medium was then evaporated under reduced pressure to provide the crude free amine as an oil. The oil was dissolved in n-propanol and treated with ethereal HCl and provided 1.2 g (56%) of white crystals: mp 88°-92° C. The NMR spectrum of the product was consistent with the assigned structure and the elemental analysis data was consistent with the molecular formula C18H30NO4Cl.

Workup

  1. temperatureto reflux for 4 hours
  2. customThe reaction medium was then evaporated under reduced pressure
  3. customto provide the crude free amine as an oil

Sources & evidence

ORD record
ord-ca51792c3e9444949329ad610460f06b
Source dataset
uspto-grants-1986_06
Patent number
US04593119

Reaction notes

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