2-Methoxynaphthalene → HCID 23319837, compound

HRID 1981655Notes

Reaction equation

HRID 1981655 reaction equation
[CH3:1][O:2][C:3]1[CH:12]=[CH:11][C:10]2[C:5](=[CH:6][CH:7]=[CH:8][CH:9]=2)[CH:4]=1.[CH2:13]=[C:14]1[O:18][C:16](=[O:17])[CH2:15]1>F>[C:16]([C:4]1[C:5]2[C:10](=[CH:9][CH:8]=[CH:7][CH:6]=2)[CH:11]=[CH:12][C:3]=1[O:2][CH3:1])(=[O:17])[CH2:15][C:14]([CH3:13])=[O:18]

Participants

4

Reactant 2

HCID 71192-MethoxynaphthaleneHCID 12661Diketene

Product 1

HCID 23319837HCID 23319837, compoundYield 88%

Reagents, catalysts & solvents 1

HCID 14917Hydrofluoric AcidSolvent

Procedure

Eiglmeier, in U.S. 4,082,807, teaches the acylation of 2-methoxynaphthalene in anhydrous hydrogen fluoride with diketene to yield 1-acetoacetyl-2-methoxynaphthalene in 88% yield at -25° C. to -35° C.

Sources & evidence

ORD record
ord-72bab2b0945943a4ac05cb1a6c425f1f
Source dataset
uspto-grants-1986_06
Patent number
US04593125

Reaction notes

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