反应详情

7-Amino-8,9-difluoro-2-methyl-6-oxo-1,2-dihydro-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid (0.5 g) and pyrrolidine (0.7 g) are suspended in N-methylpyrrolidone (10 ml), and the mixture is heated at 110°-120° C. for 5 hours in a sealed tube. The reaction mixture is concentrated to dryness under reduced pressure, and to the residue is added ethyl acetate. The resulting crystals are separated by filtration and recrystallized from N,N-dimethylformamide to give 7-amino-8-fluoro-2-methyl-6-oxo-9-(1-pyrrolidinyl)-1,2-dihydro-pyrrolo[3,2,1-ij]quinoline-5-carboxylic acid (0.2 g) as yellow cubic crystals. m.p. 296°-299° C. (decomp.)

1. temperaturethe mixture is heated at 110°-120° C. for 5 hours in a sealed tube
2. concentrationThe reaction mixture is concentrated to dryness under reduced pressure
3. additionto the residue is added ethyl acetate
4. customThe resulting crystals are separated by filtration
5. customrecrystallized from N,N-dimethylformamide